胡志强
胡志强，1978年6月生，教授，博士生导师，崂山学者。1999年7月毕业于青岛化工学院精细化工专业，获工学学士学位；2002年7月毕业于青岛科技大学应用化学专业，获工学硕士学位，2005年7月毕业于中国科学院化学所有机化学专业，获理学博士学位，同年来我校从事教学科研工作。2017年3月至今，任化学与分子工程学院副院长。主编《系统有机化学》和《有机化学学习指导》等教材2部，主讲本科生和研究生《有机化学》、《高等有机化学》、《杂环化学》等多门课程。
主要研究兴趣包括：（1）荧光化学传感器的构筑及其性能研究。设计合成了多种有机小分子荧光探针，实现了对重金属离子以及具有生理活性的有机小分子等的高选择性检测。（2）新型有机小分子荧光染料的合成及其在生物成像中的应用。构建了多类结构新颖的有机小分子荧光染料，特别是具有固有手性的荧光染料分子。（3）精细有机化学品绿色合成工艺的开发和优化。主要包括医药和农药中间体等有机精细化学品的绿色合成路线设计、工艺优化等。
招生方向：化学、应用化学、化学工程；电话：13616395863（微信同号）
作为项目负责人主持国家自然科学基金三项，山东省自然科学基金两项，山东省重点公关项目一项，重点实验室开放课题两项，企业横向课题五项。以第一作者或通讯联系人发表SCI论文50余篇，申报发明专利十二项，授权发明专利4项，多个横向项目实现了工业产业化。
作为项目负责人，主持的科研项目包括：
1）手性近红外荧光染料和荧光探针的构建及在2-HG对映异构体的检测与荧光成像分析中的应用（21977060），国家自然科学基金面上项目，2020.1-2023.12，66万元，在研。
2）新型罗丹明类近红外重金属离子荧光探针的设计、合成及在细胞成像中的应用（21171127），国家自然科学基金面上项目，2011.1-2014.12，60万元，已结题。
3）基于芳磺酰胺的新型有机管状组装体的构筑机器性能研究（20602022），国家自然科学基金青年项目，2007.1-2009.12，22万元，已结题。
4）新型罗丹明类近红外荧光探针的制备及其在重金属离子检测和生物荧光成像中的应用研究（ZR2011BM010），山东省科技厅，2011.1-2013.12，8万元，已结题。
5）基于含磺酰亚胺分子的新型有机螺旋组装体的构筑及其性能研究（Y2007B39），山东省科技厅，2007.1-2009.12，5.5万元，已结题。
6）新型pH敏感型近红外荧光染料的制备及其在恶性肿瘤组织荧光成像分析中的应用（2019GSF107078），山东省科技厅，2019.1-2021.12，15万元，在研。
7）对氯苯氧乙酸的合成开发和色酚副产亚磷酸的精制，企业横向项目，2019.6-2021.6，84万元，在研。
8）新型有机硼酸锌阻燃剂的合成及性能研究，企业横向项目，2019.1-2021.12，30万元，在研。
9）噻吩乙酸、乙酸丁卡因和钆双铵的合成，，企业横向项目，2015.1-2020.1，180万元，在研。
10）丙硫氧嘧啶的生产工艺开发，2012.10-2015.10，企业横向项目，100万元，已结题。
作为通讯联系人，近三年来发表的代表性论文：
1) Guangjin Shi, Yuedong Wang, Zhenxing Yu, Qi Zhang, Shaojin Chen, Liangzhong Xu, Kunpeng Wang, Zhiqiang Hu, The coumarin-pyrazole dye for detection of hydrogen sulfide in cells,Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2023,285,121898.
2) Xiaolei Xue, Yang Wang, Hao Zhang, Shaojin Chen, Shuyan Niu, Lingyun Cui, Kunpeng Wang, Zhiqiang Hu, A coumarin-based fluorescent probe: single-wavelength excitation, discrimination of Cys/Hcy and GSH by naked eyes, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2023,292,122410.
3) Xiaolei Xue, Hao Zhang, Guihua Chen, Guanhua Yu, Haoran Hu, Shuyan Niu, Kunpeng Wang, Zhiqiang Hu, Coumarin-cyanine hybrid: A ratiometric fluorescent probe for accurate detection of peroxynitrite in mitochondria, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2023,292,122443.
4) Chunming Yuan, Chunfang Liu, Ke Jia, Jing Liu, Kunpeng Wang, Shaojin Chen, Guangming Nan, Zhiqiang Hu, Binaphthanol-derived emitters with aggregation-induced emission, acidochromic and chiral optical properties, Journal of Molecular Structure,2023,1276,134793.
5) Guangjin Shi, Keke Tan, Shuyang Liu, Hao Zhang, Haoran Hu, Kunpeng Wang, Liangzhong Xu, Meng Li, Zhiqiang Hu, A extended benzothiadiazole derivative for a highefficiency TADF-sensitized fluorescent organic lightemitting diode, Chemical Commu-nications,2022,58,13529.
6) Shaojin Chen, Ke Jia, Ying Fang, Chunfang Liu, Chunming Yuan, Jing Liu, Kunpeng Wang, Zhiqiang Hu, Highly emissive dimethylamino naphthalenyl phenylethene derivatives for visualization of latent fingerprints and imaging of lysosomes, Dyes and Pig-ments,2022,205,109127.
7) Guangjin Shi, Yuedong Wang, Zhenxing Yu, Qi Zhang, Shaojin Chen, Liangzhong Xu, Kunpeng Wang, Zhiqiang Hu, Large steric hindrance amide modified benzothiadiazole: High contrast mechanochromic luminescence and volatile acid vapor response, Dyes and Pigments,2022,204,110471.
8) Guangjin Shi, Zhenxing Yu, Yuedong Wang, Qi Zhang, Shaojin Chen, Liangzhong Xu, Kunpeng Wang, Zhiqiang Hu, Imidazobenzothiadiazole: A new multifunction dyes for mechanochromic luminescence, acid responsing and mitochondrial staining, Dyes and Pigments,2022,205,110531.
9) Yang Wang, Guangjin Shi, Xiaolei Xue, Qi Zhang, Kunpeng Wang, Shaojin Chen, Linsheng Tang, Zhiqiang Hu, A hemicyanine-based near-infrared fluorescent probe for visualizing biothiols fluctuations induced by Ag+ in mitochondria, Journal of Photochemistry & Photobiology A: Chemistry,2022,433,114174.
10) Ying Fang, Jun Wang, Hui Yu, Qi Zhang, Shaojin Chen, Kunpeng Wang, Zhiqiang Hu, A sequential dual-key-dual-lock fluorescent probe for detection of SO2 and H2O2 in cells and mice, Sensors & Actuators B: Chemical,2022,371,132514.
11) Yang Wang, Xiaolei Xue, Qi Zhang, Kunpeng Wang, Shaojin Chen, Linsheng Tang, Zhiqiang Hu, A hemicyanine-based near-infrared fluorescent probe for vapor-phase hydrazine detection and bioimaging in a complete aqueous media, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2022,279,121406.
12) Hui Yu, Ying Fang, Jun Wang, Qi Zhang, Shaojin Chen, Kunpeng Wang, Zhiqiang Hu, Enhancing probe’s sensitivity for peroxynitrite through alkoxy modifcation of dicyanovinylchromene, Analytical and Bioanalytical Chemistry,2022,414,6779-6789.
13) Ying Fang, Ruxing Chen, Haifeng Qin, Jiajia Wang, Qi Zhang, Shaojin Chen, Yonghong Wen, Kunpeng Wang, Zhiqiang Hu, A chromene based fluorescence probe: Accurate detection of peroxynitrite in mitochondria,not elsewhere, Sensors & Actuators B:Chemical,2021,334,129603.
14) Ruixing Chen, Guangjin Shi, Jiajia Wang, Haifeng Qin, Qi Zhang, Shaojin Chen, Yonghong Wen, Jiabin Guo, Kunpeng Wang, Zhiqiang Hu, A highly sensitive ‘‘turn on” probe based on coumarin bdiketone for hydrazine detection in PBS and living cells, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2021,252,119510.
15) Yuanyuan Meng, Ying Fang, Chunming Yuan, Chunhui Du, Kunpeng Wang, Shaojin Chen, Zhiqiang Hu, 2-aryloxybenzo[d]oxazoles as deep blue solidstate emitters: Synthesis, aggregation-induced emission properties and crystal structure, Dyes and Pigments,2021,187,110534.
16) Guangjin Shi, Xinghao Gu, Haoyuan Lv, Rui Chen, Qi Zhang, Shaojin Chen, Caifeng Ding, Kunpeng Wang, Zhiqiang Hu, Hybrid coumarin-difluoroboron dyes for mitochondrial staining, Dyes and Pigments,2020,179,108430.
17) Shuo Wang, Qi Zhang, Shaojin Chen, Kunpeng Wang, Zhiqiang Hu, A diazabenzoperylene derivative as ratiometric fluorescent probe for cysteine with super large Stokes shift, Analytical and Bioanalytical Chemistry,2020,412,2687-2696.
18) Yimeng Duan, Shuo Wang, Fan Cao, Qi Zhang, Shaojin Chen, Yubing Zhang, Kunpeng Wang, Zhiqiang Hu, Facile and Highly Selective Ratiometric Fluorescence Probe Based on Benzo[5]helicene for the Detection of Hypochlorous Acid, Industrial & Engi-neering Chemistry Research,2020,59,992-999.
19) Qi Zhang, Shuo Wang, Na Zhang, Shaojin Chen, Kunpeng Wang, Zhiqiang Hu, Acrylmodified diazabenzo[ghi]perylene for fast discrimination of Cys from GSH and Hcy with high quantum yield, Sensors & Actuators B:Chemical,2020,320,128304.
20) Wenxuan Zhang, Qiang Jia, Yuanyuan Meng, Shaojin Chen, Yubing Zhang, Kunpeng Wang, Lihua Gan, Zhiqiang Hu, Dimethylamino naphthalene-based fluorescent probes for hydrogen sulfide detection and living cell imaging, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2020,228,117835.
21) Xinghao Gu, Yang Lei, Shuo Wang, Fan Cao, Qi Zhang, Shaojin Chen, Kunpeng Wang, Zhiqiang Hu, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2020,229,118003.
22) Lihua Chen, Mingchao Liu, Yan Tang, Chuangfu Chen, Xingxing Wang, Zhiqiang Hu, Preparation and Properties of a Low Fouling Magnetic Nanoparticle and Its Applicati-on to the HPV Genotypes Assay in Whole Serum, ACS Appl. Mater. Interfaces,2019,1,18637-18644.
23) Shaojin Chen, Wenxuan Zhang, Qiang Jia, Yuanyuan Meng, Kunpeng Wang, Zhiqiang Hu, Dimethylamino naphthalene-based cyanostyrene derivatives with stimuli responsive luminescent properties, Dyes and Pigments, 171(2019) 107700.
24) Jupeng Chen, Yimeng Duan, Wenjun Zheng, Qi Zhang, Qianshou Zong, Shaojin Chen, Kunpeng Wang, Zhiqiang Hu, Perylenequinone-based “turn on” fluorescent probe for hydrogen sulfide with high sensitivity in living cells, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 218(2019) 206-212.
25) Shaojin Chen, Wei Liu, Wenxuan Zhang, Zhaohai Ge, Kunpeng Wang, Lihua Gan ,Zhiqiang Hu,Dimethylamine substituted bisbenzocoumarin amides with solvatochromic and mechanochromic properties, Tetrahedron, 75(2019) 3504-3509.
26) Shaojin Chen, Wenxuan Zhang, Wei Liu, Zhaohai Ge, Kunpeng Wang, Lihua Gan, Zhiqiang Hu, Binaphthanol-based organic fluorophores with color tunability and their optical properties, CrystEngComm, 17(2019)2809-2817.
27) Kunpeng Wang, Qinglei Zhang, Xiang Wang, Yang Lei, Wenjun Zheng, Shaojin Chen, Haiyu Hu Zhiqiang Hu , A fluorescent probe based on tetrahydro[5]helicene derivative with large Stokes shift for rapid and highly selective recognition of hydrogen sulfide, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 214(2019) 487-495.
28) Shaojin Chen, Zhaohai Ge, Qiang Jia, Kunpeng Wang, Lihua Gan, Zhiqiang Hu, The Preparation of Enantiopure [6]-and [7]Helicenes from Binaphthanol, Chemistry, an Asian journal, 14(2019) 1462-1466.
29) Kunpeng Wang, Shengnan Xu, Yang Lei, Wenjun Zheng, Qi Zhang, Shaojin Chen, Haiyu Hu, Zhiqiang Hu, A coumarin-based dual optical probe for homocysteine with rapid response time, high sensitivity and selectivity, Talanta, 196(2019) 243-248..
30) Kunpeng Wang, Wunjun Zheng, Yang Lei, Sijie Zhang, Qi Zhang, Shaojin Chen, zhiqiang Hu, A thiophene-rhodamine dyad as fluorescence probe for ferric ion and its application in living cells imaging, Journal of Luminescence, 208(2019) 468-474.
31) Kunpeng Wang, Yang Lei, Ying Sun, Qiangyang Zhang, Shaojin Chen, Qi Zhang, Haiyu Hu, Zhiqiang Hu,Tetrahydro[5]helicene-based fluorescent probe for rapid and sensitive detection of bisulfite in living cells, Sensors and Actuators B: Chemical, 273(2018) 1487-1494.
32) Yang Lei, Kunpeng Wang, Shaojin Chen, Qi Zhang, Zhiqiang Hu, A fluorescent probe based on tetrahydro[5]helicene for highly selective recognition of hydrogen sulfide, Spectrochimica acta Part A, Molecular and biomolecular spectroscopy, 204(2018) 295-300.
33) Shaojin Chen, Wei Liu, Zhaohai Ge, Wenxuan Zhang, Kunpeng Wang, Zhiqiang Hu, Dimethylamine substituted bisbenzocoumarins: solvatochromic, mechanochromic and acidochromic properties, CrystEngComm, 20(2018) 5432-5441.
34) Kunpeng Wang, Yang Lei, Jupeng Chen, Zhaohai Ge, Wei Liu, Qi Zhang, Shaojin Chen, Zhiqiang Hu, The coumarin conjugate: synthesis , photophysical properties and the ratiometric fluorescence response to water content of organic solvent, Dyes and Pigments,2018,151,233-237.
35) Shaojin Chen, Wei Liu, Zhaohai Ge, Wenxuan Zhang, Kunpeng Wang, Zhiqiang Hu, Synthesis and studies of axial chiral bisbenzocoumarins: Aggregation-induced emission enhancement properties and aggregation-annihilation circular dichroism effects, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 193(2018) 141-146.
36) Kunpeng Wang, Jupeng Chen, Sijie Zhang, Yang Lei, Hua Zhong, Shaojin Chen, Xinhong Zhou, Zhiqiang Hu, Thiophene-based rhodamine as selective fluorescence probe for Fe(III) and Al(III) in living cells, Anal Bioanal Chem,2017,409,5547-5554.
37) Kunpeng Wang, Sijie Zhang, Chengdong Lu, Huishi Shang, Zhihui Jin, Shaojin Chen, Qi Zhang, Yubing Zhang, Zhiqiang Hu, A highly sensitive and selective turn-on fluorescent sensor for dihydrogen phosphate in living cells, Sensors and Actuators B,2017,247,791-796.
38) Kunpeng Wang, Yang Lei, Sijie Zhang, Wenjun Zheng, Jupeng Chen, Shaojin Chen, Qi Zhang, Yubing Zhang, Zhiqiang Hu, Fluorescent probe for Fe(III) with high selectivity and its application in living cells, Sensors and Actuators B,2017,252,1140-1145.